研究领域（方向）：

细胞膜色谱新方法研究

复杂体系目标物识别分析

色谱质谱联用分析

个人及工作简历（个人受教育及工作经历）：

1. 2023.06~今，西安交通大学药学院，硕士生导师&博士生合作导师

2. 2023.03~今，西安交通大学药学院，副教授

3. 2022.06~今，西安交通大学药学院，博士生合作导师

4. 2020.08~2023.03，西安交通大学药学院，助理教授

5. 2018.12~2019.12，美国威斯康星大学（麦迪逊分校）药学院，访问学者

6. 2014.09-2020.06，西安交通大学，药物分析学，医学博士

7. 2010.08-2014.07，西安交通大学，制药工程，工学学士

主要科研项目

[1]国家自然科学基金青年项目，82104118，Avi-tag-MrgprX2新型CMC固定相制备与中药注射剂中类过敏组分分析，2022-01-01至2024-12-31，30万元，在研，主持。

[2]中央高校基本科研业务费新教师科研支持项目，xxj032023011，5-HTR2A-SNAP-Tag/CMC及DRD2-SNAP-Tag/CMC模型的构建及应用，2023.08-2025.08，15万元，在研，主持。

[3]陕西省重点研发计划一般项目-社发领域，2023-YBSF-246，基于MrgX2受体的过敏原富集检测系统的建立及应用，2023.01-2024.12，6万元，在研，主持。

学术及科研成果、专利、论文

专利：

[1]韩省力，张涛，贺浪冲，付佳，吕艳妮，林园园．一种以聚乙烯醇微球为载体的细胞膜色谱柱及其制备方法（P），ZL201910385950.3，中华人民共和国国家知识产权局，2021．

[2]贺浪冲，韩省力，付佳，张涛，贺怀贞，林园园，吕艳妮．一种基于固定化SNAP-tag融合蛋白的细胞膜色谱柱及其制备方法（P），ZL201910385025.0，中华人民共和国国家知识产权局，2020．

[3]贺浪冲，张涛，韩省力，马维娜，曹娇，贺怀贞，刘瑞，车德路，吕艳妮．MrgprX2高表达的重组细胞及MrgprX2高表达膜受体固定相及制备方法和应用（P），ZL201710100941.6，中华人民共和国国家知识产权局，2019．

[4]贺浪冲，韩省力，张涛，吕艳妮，马维娜．一种双靶标细胞膜色谱柱及其制备方法和应用（P），ZL201710100595.1，中华人民共和国国家知识产权局，2018．

[5]吕艳妮，贺浪冲，韩省力，王娅敏，张涛，贾倩倩．一种基于生物素连接酶的定向共价固定细胞膜色谱柱及其制备方法与应用（P），2022117391098，中华人民共和国国家知识产权局，2022.12.30．

[6]韩省力，马维娜，吕艳妮，张涛，丁园园，贺浪冲．TDM智能分析系统V1.0．2024SR0218914，中华人民共和国国家版权局，2024．

代表性论文：

1. Chunlei Gao#, Tongpei Zhou#, Sihan Liu, Chenyang Miao, Jingting Feng, Yifan Ding,Yanni Lv*. Revealing receptor-ligand interactions of atypical antipsychotic drugs and screening anti-schizophrenia ingredients in Magnolia officinalis based on 5-HTR2A-SNAP-Tag/CMC and DRD2-SNAP-Tag/CMC models. Journal of Chromatography A, 2024, 1720, 464784.

2. Xin Zhang#, Yuhan Jiang#, Na Guo, Yifan Ding, Jingting Feng, Chenyang Miao,Yanni Lv*, Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. Journal of Pharmaceutical and Biomedical Analysis, 2024 Jan 20:238:115816.

3. Qianqian Jia#,Yanni Lv#, Chenyang Miao, Jingting Feng, Yifan Ding, Tongpei Zhou, Shengli Han*, Langchong He*. A new MrgprX2 cell membrane chromatography analysis model based on HALO-tag technology and its applications. Talanta, 2024, 268: 125317. Doi: 10.1016/j.talanta.2023.125317.

4. Yanni Lv#, Saisai Wang#, Yamin Wang, Xin Zhang, Qianqian Jia, Shengli Han*, Langchong He. Construction and application of covalently bonded CD147 cell membrane chromatography model based on polystyrene microspheres. Analytical and Bioanalytical Chemistry, 2023, 415(7): 1371-1383.

5. Yu Feng#,Yanni Lv#, Ting-Jia Gu#, Bingming Chen, and Lingjun Li*. Quantitative Analysis and Structural Elucidation of Fatty Acids by Isobaric Multiplex Labeling Reagents for Carbonyl-Containing Compound (SUGAR) Tags and m-CPBA Epoxidation. Analytical Chemistry, 2022, 94 (38): 13036-13042.

6. Qianqian Jia, Jia Fu, Chunlei Gao, Hong Wang, Saisai Wang, Peida Liang, Shengli Han,Yanni Lv*, Langchong He*. MrgX2-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-pseudo-allergic compound screening in Arnebiae Radix. Anal Bioanal Chem. 2022, 414: 5741-5753.

7. Yanni Lv, Saisai Wang, Peida Liang, Yamin Wang, Xin Zhang, Qianqian Jia, Jia Fu, Shengli Han*, Langchong He. Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approach. Anal Bioanal Chem. 2021, 413(11): 2995-3004.

8. Yanni Lv, Jia Fu, Qianqian Jia, Hengtao Dong, Shengli Han*, Lingjun Li*, Langchong He. A liquid chromatography tandem mass spectrometry based label-free quantification method for assessment of allergen-induced anaphylactoid reactions. Journal of the American Society for Mass Spectrometry, 2020, 31 (4): 856-863.

9. Yanni Lv, Xianpeng Shi, Jia Fu, Qianqian Jia, Yuanyuan Lin, Hongying Wang, Xin Yang, Shengli Han*. Screening potential antagonists of epidermal growth factor receptor from Marsdenia tenacissima via cell membrane chromatography model assisted by HPLC-ESI-IT-TOF-MS. Biomedical Chromatography, 2019, 33: e4569.

10. Yanni Lv, Jia Fu, Qianqian Jia, Delu Che, Yuanyuan Lin, Shengli Han*, Langchong He. Accurate quantification of β-hexosaminidase released from laboratory of allergic diseases 2 cells via liquid chromatography tandem mass spectrometry method. Journal of Chromatography A, 2018, 1578: 106-111.

11. Shengli Han#,Yanni Lv#, Fen Wei, Jia Fu, Qi Hu, Sicen Wang*. Screening of bioactive components from traditional Chinese medicines using cell membrane chromatography coupled with mass spectrometry. Phytochemical Analysis, 2018, 29: 341-350.

12. Shengli Han#,Yanni Lv#, Liyun Kong, Delu Che, Rui Liu, Jia Fu, Jiao Cao, Jue Wang, Cheng Wang, Huaizhen He, Tao Zhang, Xinzhong Dong*, Langchong He*. Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effect of drugs. Scientific Reports, 2017, 7(1): 13714.

13. 吕艳妮，付佳，孔利云，韩省力，张涛，贺浪冲*．细胞膜色谱在线HPLC-IT-TOF MS联用系统筛选分析射干中次野鸢尾黄素的抗EGFR活性作用．质谱学报，2017，38（4）：425-432．

14. Yanni Lv, Jia Fu, Xianpeng Shi, Zhiwei Yang, Shengli Han*. Screening allergic components of Yejuhua injection using LAD2 cell membrane chromatography model online with high performance liquid chromatography-ion trap-time of flight-mass spectrum system. Journal of Chromatography B, 2017, 1055-1056: 119-124.

15. Yanni Lv, Yueming Sun, Jia Fu, Liyun Kong, Shengli Han*. Screening anti-allergic components from Astragali Radix by the method of LAD2 cell membrane chromatography online with UHPLC-ESI-MS/MS system. Biomedical Chromatography, 2017, 31: e3806, 1-7.

联系方式

电子邮箱：yannilv@xjtu.edu.cn

联系电话：17868519508

联系地址：西安市雁塔西路76号西安交通大学医学部；

陕西省西安市长安区中国西部科技创新港21-5102