研究领域（方向）

主要从事抗肝癌药物筛选及药理活性研究，关注于缺氧环境下调控肿瘤生长新靶点和新机制及其靶向药物的研究，以及中药物质基础研究。

个人及工作简历

教育经历：

2013-11至2017-10，柏林自由大学，药学，博士（Dr. rer. nat.）

2010-09至2013-12，西北大学，中药学，硕士

2006-09至2010-06，西北大学，中药学，学士

博士后工作经历：

2018-03至2021-11，西安交通大学

科研与学术工作经历：

2021-10至今，西安交通大学，药学院，副教授

2018-03至2021-10，西安交通大学，药学院，助理研究员

科研和人才项目

(1)国家自然科学基金青年项目，81903643，血根碱对HIF-1α/TGF-β正反馈通路诱导的肝癌上皮间质转化的作用研究，2020-01-01至2022-12-31，主持；

(2)陕西省委组织部人才项目，陕西省千人计划“青年项目”，主持；

(3)陕西省科技厅，陕西省自然科学基金青年项目，2024JC-YBQN-0891，高三尖杉酯碱通过调控HIF-1α/ERβ/E2F1正反馈通路抑制非小细胞肺癌生长的作用及机制研究，2024-01至2025-12，主持；

(4)西安交通大学，校级基本科研业务费专项科研项目，xzy012020086，基因UBL4A与线粒体自噬蛋白Parkin的相互作用研究及其在抗肝癌药物筛选中的应用，2020-01至2022-12，主持。

学术及科研成果、专利、论文

1. Qi Su, Jingjing Wang, Jiayan Ren, Qing Wu, Kun Chen, Kaihui Tu, Yu Zhang, Sze Wei Leong, Ammar Sarwar, Xu Han, Mi Zhang, Weifeng Dai, Yanmin Zhang*. Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway. Acta Pharmacol Sin, 2024, doi: 10.1038/s41401-024-01254-3.

2. Qi Sun#,QiSu#, Gao Yujing, Zhou Kun, Song Weijie, Quan Penghe, Yang Xiaojian, Ge Zhishen, Zhang Yanmin, He Gang. Cationic Telluroviologen Derivatives as Type-I Photosensitizers for Tumor Photodynamic Theranostics. Aggregate, 2022, 4:e298.

3. Xiaoyan Guo,Qi Su, Tao Liu, Xiaoning He, Pingyun Yuan, Ran Tian, Bei Li, Yanmin Zhang*, Xin Chen*. Intelligent Gold Nanoparticles for Synergistic Tumor Treatment via Intracellular Ca2+ Regulation and Resulting On-demand Photothermal Therapy. Chemical Engineering Journal, 2022, 433:133850.

4. Qi Su, Jingjing Wang, Qing Wu, Asmat Ullah, Mohsin Ahmad Ghauri, Sarwar Ammar, Li Chen, Feng Liu, Yanmin Zhang*. Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer. Phytomedicine, 2021, 84: 153503-153512.

5. Qi Su, Qing Wu, Kun Chen, Jingjing Wang, Ammar Sarwar, Yanmin Zhang*. Induction of estrogen receptor β-mediated autophagy sensitizes breast cancer cells to TAD1822-7, a novel biphenyl urea taspine derivative. Molecular Biology Reports, 2021, Doi:10.1007/s11033-021-06950-5.

6. Mohsin Ahmad Ghauri#,Qi Su#, Asmat Ullah, Jingjing Wang, Ammar Sarwar, Qing Wu, Dongdong Zhang, Yanmin Zhang*. Sanguinarine impedes metastasis and causes inversion of epithelial to mesenchymal transition in breast cancer. Phytomedicine, 2021, 84: 153500-153510.

7. Xiaoqian Yu#,Qi Su#, Xiaowei Chang, Kun Chen, Pingyun Yuan, Tao Liu, Ran Tian, Yongkang Bai, Yanmin Zhang*, Xin Chen*. Multimodal obstruction of tumorigenic energy supply via bionic nanocarriers for effective tumor therapy. Biomaterials, 2021, 278: 121181-121191.

8. Asmat Ullah, Sze Wei Leong, Jingjing Wang, Qing Wu, Mohsin Ahmad Ghauri , Ammar Sarwar,Qi Su*, Yanmin Zhang*. Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer. Cell Death & Disease, 2021, 12:490-503.

9. Qi Su, Jingjing Wang, Mengying Fan, Mohsin Ahmad Ghauri, Asmat Ullah, Bo Wang, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang, Yanmin Zhang*. Sanguinarine disrupts the colocalization and interaction of HIF-1α with tyrosine and serine phosphorylated-STAT3 in breast cancer. Journal of Cellular and Molecular Medicine, 2020, 24: 3756-3761.

10. Qi Su, Jingjing Wang, Feng Liu, Yanmin Zhang*. Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis. Toxicology in Vitro, 2020, 66:104840-104846.

11. Qi Su, Mengying Fan, Jingjing Wang, Asmat Ullah, Mohsin Ahmad Ghauri, Bo Wang, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang, Yanmin Zhang*. Sanguinarine inhibits epithelial-mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma. Cell Death & Disease, 2019, 10: 939-953.

12. Qi Su, Günther Weindl*, Glucocorticoids and Toll-like receptor 2 cooperatively induce acute-phase serum amyloid A, Pharmacological research, 2018, 128: 145-152.

13. Qi Su, Anja Pfalzgraff, Günther Weindl*, Cell type-specific regulatory effects of glucocorticoids on cutaneous TLR2 expression and signaling, The Journal of Steroid Biochemistry and Molecular Biology, 2017, 171: 201-208.

14. Qi Su,Maria Grabowski, Günther Weindl*, Recognition of Propionibacterium acnes by human TLR2 heterodimers, International Journal of Medical Microbiology, 2017, 307 (2): 108-112.

15. Qi Su, Jiao He*, Ziye Wang, Le Lv, Yuan Suo, Jingjing Wang, Zongwei Zheng, Chuanchuan Huo, Jing Li, Intestinal anti-inflammatory effect of the rhizome extracts of Menispermum dauricum DC. on trinitrobenzene sulfonic acid induced ulcerative colitis in mice, Journal of Ethnopharmacology, 2016, 193: 12-20.

16. 张彦民；代秉玲；杨天枫；苏琪；张东东；展颖转；唐文娟；刘峰；黄精花在制备抗肿瘤药物中的应用以及基于黄精花的抗肿瘤药物组合物，2022-6-7，中国，ZL202010931030.X

联系方式：

电子邮箱：suqi201803@xjtu.edu.cn

联系地址：陕西省西咸新区中国西部科技创新港21号楼5126