研究领域（方向）

1、血管性疾病相关诊疗分子的设计、评价及应用

2、免疫检查点相关诊疗功能性单抗分子的设计、构建及评价

个人及工作简历

2017.9-2020.7 西安交通大学 药学院 药学 药学硕士

2020.9-2023.12 西安交通大学 药学院 药物化学 医学博士

2023.12至今 西安交通大学药学院 助理教授

科研项目

1.陕西省重点项目-秦创原产业创新聚集区“四链”融合专项（2024CY-JJQ-40），主持

2.中央高校基本科研业务费（理工类，11913222000012；），主持

3.中央高校基本科研业务费（学生类，11913225000015），主持

4.西安市科协青年人才托举项目（No.959202313021），主持

学术及科研成果、专利、论文

1.Wang J,Zhang J, et al. Discovery of a Targeted Prodrug System Activated by Reactive Oxygen Species to Enhance Diagnostic and Therapeutic Efficacy of Photodynamic Therapy. Journal of Medicinal Chemistry, 2025, 68: 17611-17623.

2.Wang J,Zhang J, et al. An activatable antibody conjugate for cold tumors: Synergistic ferroptosis and immunotherapy via photodynamic PD-L1 targeting. International Journal of Biological Macromolecules, 2026, 342: 150155.

3.Wang J,Zhang J, et al. Discovery of a theranostic functional mAb for visualizing the sensitivity and effectiveness of PD-L1 checkpoint therapy. Bioorganic Chemistry, 2025, 154: 107992.

4.Wang J, Chen Q, et al. Activity-based proteomic profiling: The application of photoaffinity probes in the target identification of bioactive molecules. TrAC Trends in Analytical Chemistry, 2019, 116: 110-120.

5.Wang J, Zhang J, et al. Active molecule-Based Theranostic Agents for Tumor Vasculature Normalization and Antitumor Efficacy. Chinese Chemical Letters, 2023.

6.Wang J,Zhang J, et al. Remodeling the tumor microenvironment by vascular normalization and GSH-depletion for augmenting tumor immunotherapy. Chinese Chemical Letters, 2023.

7.Wang J,Chen Q, et al. Activity-based proteomic profiling: application of releasable linker in photoaffinity probes. Drug Discovery Today, 2020, 25(1): 133-140.

8.Wang J,Si R, et al. Tumor-microenvironmental-response Bi-functional molecules for efficient imaging and anti-tumor activity therapy. European Journal of Medicinal Chemistry, 2022, 230: 114120.

9.Wang J,Zhang Q, et al. Discovery of Imaging and Therapeutic Integration Bifunctional Molecules Based on Bio-Orthogonal Reaction and Releasable Disulfide Bond. Bioconjugate Chemistry, 2022, 33(5): 918-928.

10.Wang J,Ma Y, et al. Effective and transient mapping of protein-protein interactions: Application of novel releasable photoaffinity linkers. Drug Development Research, 2022, 83(2): 368-378.

11.Wang J,Zhang J, et al. A Bifunctional Agent for Efficient Imaging of PD-L1 and Antimelanoma Activity. Bioorganic Chemistry, 2023, 141: 106912.

12.张杰，王瑾，潘晓艳，卢闻，单媛媛．一种基于β-乳糖苷酶响应的近红外一区多功能荧光链接体及制备方法和应用. CN202211174433.X. (2022-09-26)

13.张杰，王瑾，潘晓艳，卢闻，单媛媛．一种基于肿瘤缺氧微环境响应的多功能荧光链接体及制备方法和应用. CN202211175698.1. (2022-09-26)

14.张杰，王瑾，潘晓艳，卢闻，单媛媛．一种基于β-Gal响应的紫外可见型多功能荧光链接体及制备方法和应用. CN202211174416.6. (2022-09-26)

学术兼职及荣誉

陕西省药物化学专委会委员

西安药学会应用药理学专委会委员

联系方式

电子邮箱：wj2024@xjtu.edu.cn

通讯地址：陕西省中国西部科技创新港21号楼