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张彦民
发布时间:2015-07-13     作者:     浏览量:

  

  医学博士,教授,博士研究生导师
  教育部新世纪优秀人才,陕西省青年科技新星,陕西省天然药物研究与工程重点实验室副主任,西安交通大学首批“青年拔尖人才”入选者;国家自然科学基金委员会通讯评审专家。
  从事药物作用过程分析、中药药效物质基础分析、抗肿瘤药理、靶向血管药物分析等方面的研究工作。在“肿瘤血管生成抑制剂”药理模型建立和药效物质筛选方面开展了系列研究。自2009年至今在西安交通大学医学部药学院依次任讲师、硕士生导师、副教授、博士生导师、特聘研究员、教授。期间于2015年6月-2016年8月在美国Arizona State University(任职Assistant Research Scientist)进行访问学习。
  主持国家自然科学基金面上项目,国家自然科学基金青年项目,国家“十二五”重大新药创制专项,教育部新世纪优秀人才支持计划项目,中央高校基本科研业务费专项资金-青年教师跟踪支持项目,陕西省自然科学基金,陕西省重点实验室青年学术骨干培植等项目10项;参加国家重大科研仪器设备研制专项、国家自然科学基金重点、面上项目、西安市重大科技计划项目和陕西省13115科技创新工程技术研究中心项目等研究工作。
  发表论文109余篇,其中在Pharmacol Therapeut, JACS, CDDs, Org Lett, Chem Commun, SCI Reports,Can Lett,JCMM 等杂志上发表SCI论文86篇,申请国际和国家发明专利26项,授权13项。2012年获国家技术发明二等奖,2010年获陕西省优秀博士学位论文,同年获中国药学会科学技术二等奖。
      
主要学术任职:
  杂志编委:
  American Journal of Pharmacology and Therapy 杂志, Associate Editor
  Hepatoma Research  杂志  Editor Broard Member(EBM, 编委)       
  Pharmacologia 杂志,编委
  Clinics in Oncology 杂志,编委
  Journal of Radiology and Oncology杂志,编委
  Advances in Modern Oncology Research杂志,编委
  Advances in Oncology Research and Treatments 杂志,编委
  Med One 杂志,编委
  Reactive Oxygen Species 杂志,编委
  Journal of Biochemistry and Molecular Biology Research杂志,编委
  Insights in Breast Cancer杂志,编委
  《药物生物技术》杂志,编委

  委员会:
  陕西省药学会药物分析专业委员会  委员
  Asia-Pacific Association of Medical Research  会员
   受邀担任JACS, Oncotarget, Scientific Reports, Phytomdeicine, Gene, International Journal of Molecular Sciences, Molecules,International Journal of Oncology, Tumor Biology, Phytotherapy Research, Food & Function,Analytical Methods,Natural Product Research, Anti-Cancer Agents in Medicinal Chemistry,Mini-Reviews in Medicinal Chemistry, Biomedical Chromatography, Letters in drug design & discovery, Pharmaceutical Biology, Journal of Cancer Biology & Treatment等国际SCI期刊特邀审稿人。
  
主要研究方向:
  肿瘤血管生成抑制剂筛选研究;
  药物作用过程分析;
  中药药效物质基础分析

代表性10篇SCI论文:
  [1] Yinnan Chen, Yanmin Zhang (通讯). Functional and mechanistic analysis of telomerase: an anti-tumor drug target. Pharmacology and Therapeutics, 2016, 163:24-47.  (IF=11.000)
  [2] Arnaud Chevalier, Yanmin Zhang, Omar M. Khdour, Justin Kaye and Sidney M. Hecht. A Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting.  Journal of the American Chemical Society, 2016, 138:12009-12012.  (IF=13.038)
  [3] Yanmin Zhang, Shuoxing Jiang, Dongdong Zhang, Xiaoguang Bai, Sidney M. Hecht, Shengxi Chen. DNA-Affibody Nanoparticles for Inhibiting Breast Cancer Cells overexpressing HER2. Chemical communications, 2017, 53:573-576. (IF=6.567)
  [4]Bingling Dai, Wenjie Wang, Yujiao Ma, Junpeng Qi, Yingzhuan Zhan, Dongdong Zhang, Rui Liu, Yanmin Zhang(通讯). A natural product dihydroberberine increases the sensitivity of lung carcinoma to sunitinib by mediating MAPK pathway and inflammatory mediators. Journal of Cellular and Molecular Medicine, 2017, Accepted. (IF=4.938)
  [5] Arnaud Chevalier, Yanmin Zhang, Omar M. Khdour and Sidney M. Hecht*. Selective Functionalization of Antimycin A Through an N-Transacylation Reaction. Organic Letters, 2016, 18:2395-2398.  (IF=6.732)
  [6] Yanmin Zhang, Yingzhuan Zhan, Dongdong Zhang, Bingling Dai, Weina Ma, Junpeng Qi, Rui liu, Langchong He. Eupolyphaga sinensis Walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling. Scientific Reports, 2014, 4:5518.  (IF=5.228)
  [7] Zhang Dongdong, Zhang Yanmim, Lei Zheng, He Langchong. Graphene oxide/poly-L-lysine assembled layer for adhesion and electrochemical impedance detection of leukemia K562 cancer cells. Biosensors and Bioelectronics, 2013, 42:112-118.  (IF=7.476)
  [8] Yanmin Zhang, Bingling Dai, Lei Zheng, Yingzhuan Zhan, Jie Zhang, Wanli W. Smith, Xiaoli Wang, Yinnan Chen, Langchong He. A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. Cell Death and Disease, 2012, 3:e406.  (IF=5.378)
  [9] Wenjuan Luo, Xiaoli Wang, Lei Zheng, Yingzhuan Zhan, Dongdong Zhang, Jie Zhang, Yanmin Zhang (通讯). Brucine suppresses colon cancer cells growth via mediating KDR signaling pathway. Journal of Cellular and Molecular Medicine, 2013, 17:1316-1324.  (IF=4.938)
  [10] Yanmin Zhang, Langchong He, Liang Meng, Wenjuan Luo, Xuemei Xu. Suppression of tumor-induced angiogenesis by taspine isolated from Radix et Rhizoma Leonticis and its mechanism of action in vitro. Cancer Letters, 2008, 262:103-113.  (IF=5.992)
 
联系方式:
  电话: 029-82656264
  E-mail:zhang2008@xjtu.edu.cn
  单位:西安交通大学医学部药学院药物研究所
  地址:西安市雁塔西路76号
  邮编:710061
  个人主页:http://gr.xjtu.edu.cn/web/zhang2008