研究领域（方向）

（1）天然药物的研究与开发。主要从植物、中草药、植物内生真菌等中寻找结构新颖、活性显著的功效成分或先导化合物，并开展基于肿瘤、炎症性等疾病的作用机制研究。

个人及工作简历

工作经历

2019.05-至今 西安交通大学 副教授

2017.11-2018.10 英国帝国理工学院 访问学者

2015.09-2019.04 西安交通大学 讲师

教育经历

2010.09-2015.07 西北大学 博士

2006.09-2010.07 西北大学 学士

主要科研项目

主持国家自然科学基金、陕西省重点产业创新链（群）-社发项目、中国博士后基金、陕西省自然科学基金等国家级和省部级项目10余项。

1、国家自然科学基金项目，No．81603267，2016.01-2019.12，主持

2、陕西省重点产业创新链（群）-社发项目，No．2024SF-ZDCYL-03-18，2024.01-2026.12，主持

3、中国博士后科学基金特别资助项目，No．2018T111078，2017.01-2019.12，主持

4、中国博士后科学基金面上项目，No．2020M673429，2020.01-2021.12，主持

5、中国博士后科学基金面上项目，No．2016M590958，2016.01-2017.12，主持

6、陕西省自然科学基金，No．2020JM-013，2020.01-2021.12，主持

7、陕西省自然科学基金，No．2017JQ8017，2017.01-2018.12，主持

8、陕西省博士后基金，No．2017BSHEDZZ94，2017.01-2018.12，主持

9、中央高校基本科研业务费，2017.01-2018.12，主持

10、西安交通大学新讲师支持计划，No．1191320023，2016.01-2017.12，主持

学术及科研成果、专利、论文

在Food Chemistry、Food & Function、Phytochemistry、Journal of Proteome Research、Journal of Cleaner Product和Phytomedicine等杂志共发表50余篇学术论文，其中以第一作者及通讯作者共发表20余篇SCI学术论文，以第一作者和通讯作者共发表10篇中文核心期刊。申请获得4项国家发明专利。部分文章如下：

1.Xinxin Zhang, Yu Zhang, Yuting Guo, Zhaowei Xue, Yan Zhang, Hong Zhang, Yoichiro Ito, Jianwei Dou, Zengjun Guo. Research progress of diosgenin extraction from Dioscorea zingiberensis C. H. Wright: Inspiration of novel method with environmental protection and efficient characteristics. Steroids, 2023, 192, 109181.https://doi: 10.1016/j.steroids.2023.109181.

2.Muhammad Khurm, Yuting Guo, Qingqing Wu, Xinxin Zhang*, Muhammad Umer Ghori, Muhammad Fawad Rasool, Imran Imran, Fatima Saqib, Muqeet Wahid, Zengjun Guo. Conocarpus lancifolius (Combretaceae): Pharmacological effects, LC-ESI-MS/MS profiling and in silico attributes. Metabolites, 2023, 13(7),794.https://doi: 10.3390/metabo13070794.

3.Xinxin Zhang, Zhaowei Xue, Shangjun Zhu, Yuting Guo, Yan Zhang, Jianwei Dou, Jiye Zhang, Yoichiro Ito, Zengjun Guo. Diosgenin revealed potential effect against cerebral ischemia reperfusion through HIKESHI/HSP70/NF-κB anti-inflammatory axis. Phytomedicine, 2022, 153991.https:// doi: 10.1016/j.phymed.2022.153991.

4.Zhaowei Xue, Zhen Cao, Ming Jin, Xinxin Zhang*, Xinrui Wang, Jianwei Dou, Yuhong Zhu, Yoichiro Ito, Zengjun Guo. New bitter substances from medicine food homologous Dioscorea zingiberensis yam and their potential functions. Food & Function, 2021, 12(18), 8314-8325.https:// DOI: 10.1039/D1FO01301G.

5.Xinxin Zhang, Xingbin Wang, Zhaowei Xue, Guanqun Zhan, YoichiroIto, Zengjun Guo. Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscoreayam-derived diosgenin based on mediation of potential targets. Food Chemistry,2021, 345: 128672-128684.https://doi: 10.1016/j.foodchem.2020.

128672.

6.Muhammad Khurm, Xingbin Wang, Hui Zhang, Sajid Nawaz Hussain, Muhammad Naeem Qaisar, Khezar Hayat, Fatima Saqib, Xinxin Zhang*, Guanqun Zhan, Zengjun Guo. The genus Cassia L.: Ethnopharmacological and phytochemical overview. Phytotherapy Research, 2020, 1-50. https:// doi: 10.1002/ptr.6954.

7.Xinxin Zhang, Xingbin Wang,Muhammad Khurm, Guanqun Zhan, Hui Zhang,Yoichiro Ito, Zengjun Guo. Alterations of brain quantitative proteomicsprofiling revealed the molecular mechanisms of diosgenin against cerebralischemia reperfusion effects. Journal of Proteome Research, 2020, 19(3): 1154-1168. https:// doi: 10.1021/

acs.jproteome.9b00667.

8.Xinxin Zhang, Ming Jin, Nigatu Tadesse, Guanqun Zhan, Hui Zhang,Jun Dang, Sicen Wang, Zengjun Guo, Yoichiro Ito. Methods to treat the industrial waste water in diosgenin enterprises produced from Diosorea zingiberensis C. H. Wright. Journal of Cleaner Production. 2018, 186: 34-44. https://https://doi.org/10.1016

/j.jclepro.2018.03.124.

9.Xinxin Zhang, Guanqun Zhan, Ming Jin, Hui Zhang, Jun Dang, YanZhang, Zengjun Guo, Yoichiro Ito. Botany, traditional use, phytochemistry, pharmacology,quality control, and authentication of RadixGentianae Macrophyllae-A traditional medicine: A review. Phytomedicine,2018, 46: 142-163.https:// doi: 10.1016/j.phymed.2018.

04.020.

10.Xinxin Zhang, Ming Jin, Nigatu Tadesse, Jun Dang, Tao Zhou, HuiZhang, Sicen Wang, Zengjun Guo, Yoichiro Ito. Dioscorea zingiberensis C. H. Wright: An overview on its Traditional Use, Phytochemistry, pharmacology, clinical applications, quality control, and toxicity.Journal of Ethnopharmacology, 2018, 220: 283-293.https:// doi: 10.1016/j.jep.2018.03.017.

联系方式

电子邮箱：zhangxinxin360@126.com

zhangxinxin360@mail.xjtu.edu.cn

个人主页：http://gr.xjtu.edu.cn/en/web/zhangxinxin360/home

联系地址：

西安交通大学雁塔校区：陕西省西安市雁塔区雁塔西路76号

西安交通大学创新港校区：陕西省咸阳市秦都区钓台街道