研究领域（方向）

1.凝血因子抑制剂筛选

2.电化学发光生物传感器

个人及工作简历

科研项目

学术及科研成果、专利、论文

科研奖励

[1] “二维联用色谱技术在药物筛选和乳制品分析中的应用”获2016年度陕西高等学校科学技术奖励一等奖王嗣岑，侯晓芳，韩省力，张涛，解笑瑜，张杰

[2] “二维联用色谱技术在药物筛选和乳制品分析中的应用”获2017年度陕西省科学技术奖励二等奖王嗣岑，侯晓芳，韩省力，张涛，解笑瑜，张杰

发明专利

[1]一种合成塔斯品碱的方法（ZL 200810232351.X）

[2]一种FGFR4高表达的重组HEK293细胞及其应用 (201110269675.2)

软件著作

[1] RI-2D二维色谱智能分析（数据处理）系统V1.0

登记号:2015SR169873

贺浪冲，王嗣岑，孙萌，张杰，侯晓芳.

[2] 配体-受体相互作用分析系统V1.0

登记号2015SR206223

贺浪冲，王嗣岑，孙萌，张杰，侯晓芳，马维娜.

研究论文

[1] Yanru Qiao, Yingdi Shi, Chen Wu,Xiaofang Hou*, Xiaoyan Pan, Zijie Deng, Sicen Wang*. Rapid screening and identification of anticoagulation component from carthami flos by two-dimensional thrombin affinity chromatography combined with HPLC-MS/MS. Journal of Separation Science. 2021, 44(16):3061-9.

[2]Xiaofang Hou, Sun Meng, Bao Tao, Xie Xiaoyu, Wei Fen, Wang Sicen. Recent advances in screening active components from natural products based on bioaffinity techniques. Acta Pharmaceutica Sinica B. 2020.10(10): 1800-1813。

[3] Yingdi Shi, Sun Wei, Pan Xiaoyan,Hou Xiaofang*, Wang Sicen*, Zhang Junbo*. Establishment of thrombin affinity column (TAC)-HPLC-MS/MS method for screening direct thrombin inhibitors from Radix Salviae Miltiorrhiae. J Chromatogr B. 2020,1139:121894.

[4] Ping Zhang, Shi Yingdi, He Xiaoshuang, Sun Wei, Lv Yanni,Hou Xiaofang*. Study on screening potential allergenic proteins from infant milk powders based on human mast cell membrane chromatography and histamine release assays. Journal of Pharmaceutical Analysis. 2019,9(1):55-61.

[5] Dan Xu, Wang Sicen,Hou Xiaofang, Sun Changshan. Preliminary Studies on Liquiritin, Deoxyschizandrin, and Tanshinone II A as Potential Anti-Neurodegenerative Disease Agent: Determination by Reverse-Phase Liquid Chromatography in Tianwang Buxin Pills. Journal of Analytical Methods in Chemistry. 2019,2019:1-8.

[6] Xiaoshuang He, Ping Zhang, Muhammad Saqib,Xiaofang Hou*, Sicen Wang. Screening active anti-breast cancer compounds from cortex magnolia officinalis by MCF-7 cell membrane chromatography coupled with UHPLC-ESI-MS/MS. Anal. Methods, 2017, 9(33): 4828-4836.

[7]Xiaofang Hou, Hu Yin, Wang Ping, Yang Liju, Al Awak Mohamad M., Tang Yongan, Twara Fridah K., Qian Haijun, Sun Ya-Ping. Modified facile synthesis for quantitatively fluorescent carbon dots. Carbon. 2017,122:389-394.

[8] Hu, Y.; Al Awak, M. M.; Yang, F.; Yan, S.; Xiong, Q.; Wang, P.; Tang, Y.; Yang, L.; LeCroy, G. E.;Hou, X.; Bunker, C. E.; Xu, L.; Tomlinson, N.; Sun, Y. P., Photoexcited State Properties of Carbon Dots from Thermally Induced Functionalization of Carbon Nanoparticles. Journal of materials chemistry. C, Materials for optical and electronic devices 2016, 4 (44), 10554-10561.

[9] Wang, P.; Liu, J.-H.; Gao, H.; Hu, Y.;Hou, X.; LeCroy, G. E.; Bunker, C. E.; Liu, Y.; Sun, Y.-P., Host–guest carbon dots as high-performance fluorescence probes. J. Mater. Chem. C 2017, 5 (25), 6328-6335.

[10] Meng Sun¹,Xiaofang Hou¹, Yuanyuan Lin, Jie Zhang and Sicen Wang. An improved cell membrane chromatography method for the simultaneous screening of two epidermal growth factor receptor antagonists from radix scutellariae. Journal of Separation Science. 2015, 38(22):3832-9314

[11]Xiaofang Hou,MengSun，Xiaoshuang He, Liang Chen, Ping Zhang, Langchong He. Simultaneous quantification of five proteins and seven additives in dairy products with the heart-cutting two-dimensional liquid chromatography method. Journal of Separation Science. 2015, 38(22): 3832-3838.

[12]Xiaofang Hou,Jing Ma, Xiaoshuang He, Liang Chen, Sicen Wang, Langchong He. A stop-flow two-dimensional liquid chromatography method for determination of food additives in yogurt. Analytical Methods. 2015, 7, 2141-2148.

[13] Peng Zhang,Xiaofang Hou,Nan Lv, Liuxin Feng, Sicen Wang. Cell Membrane Chromatography with Zonal Elution for Characterization of Seven Alkaloids Binding to α1A Adrenoreceptor. Journal of Liquid Chromatography & Related Technologies 2015, 38, 986-992.

[14]Xiaofang Hou, Sicen Wang, Tao Zhang, Jing Ma, Jie Zhang, Yanmin Zhang, Wen Lu, Huaizhen He, Langchong He*. Recent advances in cell membrane chromatography for traditional Chinese medicines analysis. Journal of Pharmaceutical and Biomedical Analysis. 2014,101: 141-150

[15] Jing Ma, Bing Zhang, Yunan Wang,Xiaofang Hou*. Comparison of Six Sample Preparation Methods for Analysis of Food Additives in Milk Powder. Food Analytical Methods. 2014,7(6):1345-1352

[16] Jing Ma, Bing Zhang, Yunan Wang,Xiaofang Hou*, Langchong He. Determination of flavor enhancers in milk powder by one-step sample preparation and two-dimensional liquid chromatography. Journal of Separation Science. 2014;37(8):920-926.

[17] Jing Ma,Xiaofang Hou, Bing Zhang, Yunan Wang, Langchong He. The analysis of carbohydrates in milk powder by a new “heart-cutting” two-dimensional liquid chromatography method. Journal of Pharmaceutical and Biomedical Analysis. 2014 25;91:24-31.

[18]Xiaofang Hou, Xilong Yuan, Bing Zhang, Sicen Wang. Screening active anti‐breast cancer compounds from Cortex Magnolia Officinalisby two dimensional liquid chromatography‐mass spectroscopy. Journal of Separation Science. 2013, 36, 706–712

[19] Xilong Yuan, Bing Zhang, Yunan Wang, Jing Ma,Xiaofang Hou*. An online coupled breast cancer cell membrane chromatography with HPLC/MS for screening active compounds from Fructus evodiae. Analytical Methods, 2013,5, 5767-5774.

[20]Xiaofang Hou, Sicen Wang, Jingjing Hou, Langchong He. Establishment of A431 Cell Membrane Chromatography-RPLC Method for Screening Target Components from Radix Caulophylli. Journal of Separation Science. 2011, 34, 508–513

[21] Miao Li,Xiaofang Hou, Sicen Wang, Qiang Fu, Langchong He. Applications of HPLC/MS in the analysis of traditional Chinese medicines. Journal of Pharmaceutical Analysis, 2011. 1(2): 81-91.

[22]Xiaofang Hou, Jing Ren, Sicen Wang, Langchong He. Establishment of a High Expression of a_1AAdrenergic Receptor Cell Membrane Chromatography-RPLC Method for Screening Target Components from Radix Caulophylli. Chromatographia. 2010, 72: 635-640

[23]Xiaofang hou, Mingzhe Zhou, Qiao Jiang, Sicen Wang, Langchong He. A Vascular Smooth Muscle Cell Membrane Chromatography-Offline-GC/MS Method for Recognition, Separation and Identification of Active Components from Chinese Traditional Medicines. Journal of Chromatography A. 2009,1216: 7081-7087

[24]XiaoFang Hou, ZhuJun Zhang, Yan Zhao, Jie Ma. Microdialysis sampling and chemi -luminescence detection for in vivo and real-time study of the lead metabolism in rabbit blood. Microchimica acta. 2007, 159: 223–228

[25] Langchong He, Sicen Wang, Guangde Yang, Yanmin Zhang, Changhe Wang, Bingxiang Yuan,Xiaofang Hou. Progress in cell membrane chromatography. Drug discoveries & therapeutics 2007, 1, 104.

[26]侯晓芳,施迎娣,王嗣岑. 中药及保健品中非法添加物的分析技术研究进展. 中国药科大学学报. 2019,50(1):33-40

[27]侯晓芳, 王嗣岑, 张涛, 贺浪冲.细胞膜色谱法应用于中药质量控制的思考. 世界科学技术-中医药现代化. 2014,16(3): 526-528.

[28]侯晓芳, 杜晖, 贺晓双, 张平, 王嗣岑. 细胞膜色谱法用于药物与受体相互作用研究进展. 药学进展. 2015, 39(12):882-888.

[29]侯晓芳，章竹君，赵琰，马杰. 流动注射化学发光法测定面粉中的增白剂-过氧化苯甲酰. 陕西师范大学学报（自然科学版）.2006,34(1): 67-70

[30]肖娜,侯晓芳,崔亚丽,陈超.微型流动注射化学发光仪测定蔬菜中残留的有机磷农药.西北大学学报（自然科学版）.2007,37(5): 767-770

联系方式

电子邮箱：houxiaofang@mail.xjtu.edu.cn

联系电话：18009210696

个人主页：http://gr.xjtu.edu.cn/en/web/houxiaofang

联系地址：中国西部创新港21号巨构21-5132