研究领域（方向）

研究方向为药物新剂型设计、药物作用及稳定性评价。

个人及工作简历

2014.12-今 西安交通大学医学部药学院 药剂学专业副教授

2011.2-2014.12西安交通大学医学部药学院药剂学专业 讲师

2000.9-2004.7西安交通大学药学院药学专业 获理学学士学位

2004.9-2007.5西安交通大学医学院药物分析专业 获医学硕士学位

2007.9-2010.12西安交通大学医学院药理专业 获医学博士学位

科研项目

[1] 2017.1-2018.12 陕西省自然科学基金“杨梅素对白色念珠菌生物膜的抑制作用及机制研究” （主持） 项目编号：2017JM8069

[2] 2015.1-2017.12 国家自然科学基金项目“SIRT1介导的新型一氧化氮供体型α糖苷酶抑制剂对糖尿病血管病变的作用及机制研究”（主持） 项目编号：81402925

[3] 2012.4-2014.3 陕西省自然科学基础研究计划项目“双丙戊酸纳-伊马替尼”联合抗白血病作用研究” （主持） 项目编号：2012JQ4025

学术及科研成果、专利、论文

论文：

[1] Peipei Zhang, Xiaofeng Yang, Yanhao He, Zhuo Chen, Bing Liu, Cota Segura Emesto, Guangde Yang, Weirong Wang, Jiye Zhang* & Rong Lin Preparation, characterization and toxicity evaluation of amphotericin B loaded MPEG-PCL micelles and its application for buccal tablets. Applied Microbiology and Biotechnology 2017: 101(19): 7357–7370 IF: 3.42

[2] Li Zhou, Peipei Zhang, Zhuo Chen, Shaona Cai, Ting Jing, Huihui Fan, Fei Mo, Jiye Zhang*, Rong Lin. Preparation, characterization, and evaluation of amphotericin B-loaded MPEG-PCL-g-PEI micelles for local treatment of oral candida albicans. International Journal of Nanomedicine. 2017:12 4269–4283 IF: 4.32

[3] Shaona Cai, Peipei Zhang, Li Zhou, Ting Jing, Huihui Fan, Rong Lin, Guangde Yang, Weirong Wang, Jiye Zhang*. Determination and correlation of the solubility of myricetin in ethanol and water mixtures from 288.15 to 323.15K. Physics and Chemistry of Liquids 2016, 55(1) 27-37 IF: 1.111

[4] Li Zhou, Ting Jing, Peipei Zhang, Liqin Zhang, Shaona Cai, Tingting Liu, Huihui Fan, Guangde Yang1,Rong Lin, and Jiye Zhang*. Kinetics and Modeling for Extraction of Chrysin from Oroxylum indicum Seeds. Food Science Biotechnology. 2015, 24(6): 2045-2050 IF: 0.699

[5] Yanxiang Li, Guangde Yang, Xiaofeng Yang, Yanhao He, Weirong Wang, Jiye Zhang, Tingting Li, Wei Zhang, Rong Lin. Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway. The Journal of nutritional biochemistry 2015, 26(11):1338-1347 IF: 4.668

[6] Peipei Zhang, Shaona Cai, Li Song, Liqin Zhang, Huihui Fan, Li Zhou, Rong Lin, Guangde Yang, Xiaoli Bian, Weirong Wang, Jiye Zhang*. Solubility of dihydromyricetin in ethanol and water mixtures from 288.15 to 323.15 K. Journal of Molecular Liquids 2015, 211:197-202 IF: 2.740

[7] Xiaofeng Yang, Yanxiang Li, Yanhao He, Tingting Li, Weirong Wang, Jiye Zhang, Jingyuan Wei, Yanhong Deng, Rong Lin. Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process. International immunopharmacology 2015, 26(2):401-408 IF: 2.551

[8] R. Lin, L. Zhang, P. Zhang, L. Zhou, T. Liu, Y. Li, W. Zhang, W. Wang, J. Zhang*. Influence of CYP2C19 loss-of-function variants on the metabolism of clopidogrel in patients from north-western China. Journal of Clinical Pharmacy and Therapeutics 2015, 40(3), 308-314 IF: 1.339

[9] Liqin Zhang, Li Song, Peipei Zhang, Tingting Liu, Li Zhou, Guangde Yang, Rong Lin, Jiye Zhang*. Solubilities of Naringin and Naringenin in Different Solvents and Dissociation Constants of Naringenin. Journal of Chemical & Engineering Data 2015, 60(1), 932 −940 IF: 1.835

[10] Jiye Zhang, Peipei Zhang, Tingting Liu, Li Zhou, Liqin Zhang, Rong Lin, Guangde Yang, Weirong Wang, Yiping Li. Solubility of naringin in ethanol and water mixtures from 283.15 to 318.15 K. Journal of Molecular Liquids 2015, 20(3), 98-103 IF: 2.740

[11] Weirong Wang, Jianfeng Zhang, Yanxiang Li, Xiaofeng Yang, Yanhao He, Tingting Li, Feng Ren, Jiye Zhang*, Rong Lin. Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1. Cancer Letters 2015, 356(2):791-799 IF: 5.992

[12] Ke Wang, Tingting Liu, Rong Lin, Bing Liu, Guangde Yang, Xin Bu, Weirong Wang, Peipei Zhang, Li Zhou, Jiye Zhang*. Preparation andin vitro release of buccal tablets of naringenin-loaded MPEG-PCL nanoparticles. RSC Advances 2014, 4, 33672–33679 IF: 3.289

[13] Jiye Zhang, Li Zhou, Peipei Zhang, Tingting Liu, Guangde Yang, Rong Lin, Jun Zhou*. Extraction of polydatin and resveratrol from Polygonum cuspidatum root: Kinetics and modeling. Food and Bioproducts Processing. 2014, 94:518-524 IF: 2.687

[14] Li Zhou, Peipei Zhang, Guangde Yang, Rong Lin, Weirong Wang, Tingting Liu, Liqin Zhang, Jiye Zhang*. Solubility of chrysin in ethanol and water mixtures. Journal of Chemical & Engineering Data 2014, 59 (7), 2215–2220 IF: 2.037

[15] Weirong Wang, Ling Bai, Hu Qiao, Yanxiang Li, Lina Yang, Jiye Zhang, Rong Lin, Feng Ren, Jianfeng Zhang, Meixi Ji. The Protective Effect of Fenofibrate against TNF-α-Induced CD40 Expression through SIRT1-Mediated Deacetylation of NF-κB in Endothelial Cells. Inflammation 2014, 37(1):177-85 IF: 2.618

[16] Peipei Zhang, Rong Lin, Guangde Yang, Jiye Zhang*, Li Zhou, Tingting Liu. Solubility of Naringenin in Ethanol and Water Mixtures. Journal of chemical and engineering data. 2013, 58 (9), 2402–2404 IF: 1.835

[17] Weirong Wang Qinqin Lin Rong Lin Jiye Zhang Feng Ren Jianfeng Zhang Meixi Ji Yanxiang Li. PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. Experimental Cell Research 2013, 319(10):1523-1533 IF: 3.592

[18] Weirong Wang, Chunfang Yan, Jiye Zhang, Rong Lin, Qinqin Lin, Lina Yang, Feng Ren, Jianfeng Zhang, Meixi Ji, Yanxiang Li. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis 2013, 18(6):689-701

[19] Yang Lina. Zhang Jiye. Yan C. SIRT1 regulates CD40 expression induced by TNF-alpha via NF-kB pathway in endothelial cells. Cellular Physiology and Biochemistry 2013, 30: 1287-1298. IF: 3.415

[20] Wang Weirong, Lin Rong, Zhang Jiye, et. al. Involvement of fatty acid metabolism in the hepatotoxicity induced by divalproex sodium. Human & Experimental Toxicology, 2012, 31(11): 1092-1101. IF: 1.604

[21] Qiaoli Ji, Lina Yang, Jun Zhou, Rong Lin, Jiye Zhang, Qinqin Lin, Weirong Wang, Kaifan Zhang. Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1α pathway. Toxicology in Vitro 2012, 26(3):455-461 IF: 3.338

[22] Yiping Li, Jiye Zhang, Delong He, Qi Liang, Yawen Wang. Characterization of molecular recognition of Phosphoinositide-3-kinase α inhibitor through molecular dynamics simulation. Journal of Molecular Modeling, 2012, 18(5): 1907-1916. IF: 1.438

[23] Jiye Zhang, Guangde Yang, Rong Lin*, et al.. Determination of paeoniflorin, calycosin-7-O-β-D-glucoside, ononin, calycosin and formononetin in rat plasma after oral administration of Buyang Huanwu Decoction for their pharmacokinetic studies by liquid chromatography–mass spectrometry, Biomedical Chromatography 2011, 25: 450-457 IF: 1.639

[24] Yu Liu, Rong Lin, Xiaolian Shi, Zhiyuan Fang, Weirong Wang, Qinqin Lin, Jiye Zhang, Hui Zhang, Qiaoli Ji. The Roles of Buyang Huanwu Decoction in Anti-Inflammation, Antioxidation and Regulation of Lipid Metabolism in Rats with Myocardial Ischemia. Evidence-based Complementary and Alternative Medicine 2011, 2011(4):1-8 IF: 1.931

[25] Hui Zhang, Weirong Wang, Rong Lin, Jiye Zhang, et al. Buyang Huanwu decoction ameliorates coronary heart disease with Qi deficiency and blood stasis syndrome by reducing CRP and CD40 in rats. Journal of Ethnopharmacology. 2010, 130: 98-102 IF: 3.055

[26] Rong Lin, Jiye Zhang, Zhen Hu, et al. Determination of six bioactive compounds in Buyang Huanwu decoction by high performance liquid chromatography coupled with electrospray mass spectrometry, Analytical Letters 2010, 43(18):2905-2912 IF: 1.317

[27] Qiaoli Ji, Xiaolian Shi, Rong Lin, Youhua Mao, Xiaogang Zhai, Qinqin Lin, Jiye Zhang. Participation of lipid transport and fatty acid metabolism in valproate sodium-induced hepatotoxicity in HepG2 cells. Toxicology in Vitro 2010, 24(4):1086-91 IF: 3.338

[28] Jiye Zhang, Guangde Yang, Zhen Hu, Langchong He, Hao Li. LC–ESI–MS Determination of Imperatorin in Rat Plasma After Oral Administration and Total Furocoumarins of Radix Angelica dahuricae and its Application to a Pharmacokinetic Study, Chromatographia 2009, 69: 859–864 IF: 1.332

[29] Guangde Yang, Li Zhang, Baolu Feng, Jiye Zhang. Validation and Application by LC for Simultaneous Determination of Imperatorin and Isoimperatorin in Traditional Chinese Medicinal Preparations Containing Radix Angelicae dahuricae. Chromatographia 2008, 68: 869–871 IF: 1.332

[30] Guangde Yang, Rong Lin, Zhen Hu, Jiye Zhang, Chunjie Han, Langchong He, Weirong Wang. Establishment of the Model CD40 Cell Membrane Chromatography and Its Chromatographic Characteristics. Chromatographia 2008, 67(9):829-831 IF: 1.332

[31] Mingjin Liang, Jiye Zhang, Runhui Liu, Shikai Yan, Weidong Zhang, Min Lin. Chemical Profile of Danning Tablets by LC-DAD Coupled with ESI-MS，Chromatographia 2007, 66: 107–110 IF: 1.332

[32] Runhui Liu, Jiye Zhang, Mingjin Liang, Weidong Zhang, Shikai Yan, Min Lin. Simultaneous analysis of eight bioactive compounds in Danning tablet by HPLC-ESI-MS and HPLC-UV，Journal of Pharmaceutical and Biomedical Analysis 2007, 43, 1007–1012 IF:2.453

专利 ：

[1] 张继业，林蓉，刘婷婷. 一种测量生物黏附制剂体外释放度及黏附时间/溶蚀时间的的装置. 实用新型专利 专利号：ZL 201320445613.7

[2] 张继业，林蓉，刘婷婷. 一种测量生物黏附制剂体外释放度及黏附时间/溶蚀时间的的方法. 发明专利 专利号：201310314847.2

[3] 张继业，林蓉，许加成. 一种测量生物粘附制剂体外粘附力的装置 实用新型专利 专利号：ZL201320673633.X

[4] 林蓉，张继业，李亚楠，王维蓉，杨广德，曾爱国，边晓丽，丁书江. 一种阿司匹林的晶型及制备方法和应用. 发明专利 专利号：ZL201410333561.3

[5] 林蓉，边晓丽，张继业，张玮，杨广德，王维蓉，栾亚军，张丽琴，厉彦翔，杨小丰，张沛沛，周莉，何延浩，谢允东，蔡少娜，景婷. 一种羟基酪醇NO供体衍生物及其制备方法和应用. 发明专利 专利号：ZL20151058108.0

[6] 杨广德，贺浪冲，张继业，张莉，张燕，曹永孝，边晓丽.中药蛇床子有效成分欧前胡素和蛇床子素的提取方法. 发明专利 批准号：ZL200610042997.2

[7] 杨广德，张继业，曾爱国，宋鑫. 一种使用冷冻干燥技术对生物样品进行前处理的方法. 发明专利 批准号：ZL200910021637.8

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