研究领域（方向）

1.酪氨酸激酶抑制剂抗肿瘤药物研究；

2.计算机辅助药物设计。

个人及工作简历

科研项目

学术及科研成果、专利、论文

已发表论文（1）Xiaoyan Pan, Liyuan Liang, Ying Sun, Ru Si, Qingqing Zhang, Jin Wang, Jia Fu, Junjie Zhang, Jie Zhang*. Discovery of novel Bcr-Abl^T3151inhibitors with flexible linker. Part 1: Confirmation optimization of phenyl-1H-indazol-3-amine as hinge binding moiety. European Journal of Medicinal Chemistry, 2019, 178: 232-242.

（2）Xiaoyan Pan, Liyuan Liang, Ru Si, Jin Wang, Qingqing Zhang, Huaxin Zhou, Lin Zhang, Jie Zhang^*, Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol. European Journal of Medicinal Chemistry, 2019, 163: 1-9.

（3）Jinyun Dong, Qijing Zhang, Qing Cui, Guang Huang,Xiaoyan Pan*, Shaoshun Li*. Flavonoids and Naphthoflavonoids: Wider Roles in the Modulation of Cytochrome P450 Family1 Enzymes[J]. ChemMedChem, 2016, 11(19): 2102-2118.

（4）Xiaoyan Pan, Jinyun Dong, Ruili Shao, Ping Su, Yaling Shi, Jinfeng Wang, Langchong He. Expanding the structural diversity of Bc-Abl inhibitors: Hybrid molecules based on GNF-2 and Imatinib[J]. Bioorganic & Medicinal Chemistry Letter, 2015, 25(19): 4164-4168.

（5）Xiaoyan Pan, Jinyun Dong, Yaling Shi, Ruili Shao, Fen Wei, Jinfeng Wang, Jie Zhang^*, Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as flexible linker. Organic & Biomolecular Chemistry, 2015, 13(25): 7050-7066.

（6）Xiaoyan Pan, Jinyun Dong, Hongping Gao, Fang Wang, Yanmin Zhang, Sicen Wang, Jie Zhang^*, Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors. Chemical Biology & Drug Design, 2014, 83(5): 592-599.

（7）Xiaoyan Pan, Fang Wang, Yanmin Zhang, Hongping Gao, Zhigang Hu, Sicen Wang, Jie Zhang^*, Design, synthesis and biological activities of Nilotinib derivatives as antitumor agents. Bioorganic & Medicinal Chemistry, 2013, 21(9): 2527-2534.

（8）Xiaoyan Pan, Wen Lu, Pengfei Li, Fang Wang, Chen Wang, Zhigang Hu, Jie Zhang. A novel and facile synthetic approach for Tasigna[J]. Medicinal Chemistry, 2012, 8(5): 985-989.

（9）Xiaoyan Pan, Chen Wang, Fang Wang, Pengfei Li, Zhigang Hu, Yuanyuan Shan, Jie Zhang. Development of 5-fluorouracil derivatives as anticancer agetns. Current Medicinal Chemistry, 2011, 18(29): 4538-4556.

授权发明专利

（1）张杰；贺怀贞；潘晓艳；贺浪冲；卢闻；张涛；王嗣岑，一种N,6二苯基嘧啶-4-胺类Bcr-Abl抑制剂及其制备方法和应用，2017-06-08，中国，ZL201410437921.4。

（2）张杰；贺浪冲；潘晓艳；卢闻；张涛；王嗣岑；董金云；苏萍，一种5-苯基烟酰胺类Bcr-Abl抑制剂及其制备方法和应用，2017-01-04，中国，ZL201410437551.4。

（3）张杰；贺怀贞；潘晓艳；贺浪冲；卢闻；张涛；王嗣岑，一种N,6二苯基嘧啶-4-胺类Bcr-Abl抑制剂及其制备方法和应用，2017-01-11，中国，ZL201410438745.6。

（4）贺浪冲；张杰；潘晓艳；卢闻；张涛；董金云；王嗣岑；贺怀贞，一种6-苯基吡啶-2-胺类Bcr-Abl抑制剂及其制备方法和应用，2017-06-27，中国，ZL201410437924.8。

（5）贺浪冲；张杰；潘晓艳；卢闻；张涛；王嗣岑；董金云，一种5-苯基吡啶-2-胺类Bcr-Abl抑制剂及其制备方法和应用，2017-06-27，中国，ZL201410437413.6。

获得学术奖励

（1）潘晓艳(5/6)；秦巴山区特有活性生物碱结构优化关键技术体系及其应用，陕西省人民政府，陕西省技术发明奖，二等奖，2019(张杰；卢闻；王嗣岑；单媛媛；潘晓艳；李鹏飞).

（2）潘晓艳(4/9)；秦巴山区特有活性生物碱(Taspine)的结构优化研究，陕西省教育厅，陕西高等学校科学技术奖，一等奖，2019(张杰，卢闻，单媛媛，潘晓艳，代秉玲，李鹏飞，师亚玲，魏芬，司茹).

联系方式

电子邮箱：panxy2016@xjtu.edu.cn

联系电话：

个人主页：无

联系地址：西安市雁塔西路76号