硕导

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毛 帅
发布时间:2022-09-26     作者:     浏览量:



研究领域(方向):

1) 化学药物绿色合成方法和工艺研究;

2) 硒化学及含硒活性分子的研究;

3) 生物催化

个人及工作简历(个人受教育及工作经历):

毛帅,男,西安交通大学副教授,硕士研究生导师。2009年7月获得中北大学制药工程专业工学学士学位,2012年7月、2015年7月分别获西北大学有机化学专业理学硕士学位和理学博士学位,博士论文被评选为西北大学优秀博士论文;2015年10月作为讲师入职西安交通大学药学院,分别于2017年3月、2022年4月在美国密西根大学安娜堡分校(The University Of Michigan Ann Arbor)作为博士后和副研究员从事研究工作;2019年7月晋升为副教授,2020年被评选为西安交通大学优秀班主任。

主要科研项目

1) 国家自然科学基金青年项目,21602169,新型亲电硒化试剂的研究,2017.01~2019.12,主持。

2) 中国博士后科学基金面上资助项目,2016M592775,新型高价碘类亲电硒化试剂的研究,2016.01~2018.12,主持。

3) 西安交通大学新教师科研支持计划,1191320029,具有喹唑啉骨架的EGFR(T790M)抑制剂的研究,2015.10~2019.07,主持。

4) 中央高校基本科研业务费,1191320046,新型99mTc-膦酸类骨显像剂的设计合成及生物性质研究,2020-01~2021-12,主持。

5) 横向项目,3211000066,茶叶中有机硒含量检测关键技术开发,2020.10-2021.10,主持。

6) 横向项目,202009157,富硒香菇中活性成分提取及生物活性研究,2021.06- 2022.06,主持。

7) 横向项目,202207147,含硼抗菌药物开发,2022.03- 2024.03,主持。

8) 横向项目,20201016,3,4-环氧环己基甲酸-3',4'-环氧环己基甲酯的合成工艺研究,2020.10-2022.9.

学术及科研成果、专利、论文

论文:

1) Xue-Yan Yang, Bo Yuan, Hai Xiong,* Yahao Zhao, Lu Wang, San-Qi Zhang,* andShuai Mao.*Allyl phenyl selenides as H2O2acceptors to develop ROS-responsive theranostic prodrugs. 2022, Doi:10.1016/j.bioorg.2022.106154.

2) ShuaiMao,*Yahao Zhao, Zixuan Luo, Ruizhe Wang, Bo Yuan, Linghao Hu, San-Qi Zhang, Mingliagn Wang, and Zhengkai Chen. "Metal-free photo-induced sulfidation of aryl iodide and other chalcogenation."Frontiers in Chemistry10:941016. DOI: 10.3389/fchem. 2022.941016.

3) Shuai Mao,*Bo Yuan, Xinyu Wang, Yahao Zhao, Lu Wang, Xueyan Yang, Yiming Chen, San-Qi Zhang,*Pengfei Li.*Triazene as the Directing Group Achieving Highly Ortho Selective Diborylation and Sequential Functionalization.Organic Letters2022,24,3594-3598.

4) Ruizhe Wang,#Xinyu Wang,#Shuai Mao,*Yahao Zhao, Bo Yuan, Xueyan Yang, Jianjun Li, Zhengkai Chen.* Metal‐free Photochemical C‐Se Cross‐Coupling of Aryl Halides with Diselenides.Advanced Synthesis & Catalysis2022,364,1607-1612.

5) Ting Deng,#Wenxin Yan,#Xiaoyu Liu,#Guizhimeng Hu, Weilie Xiao,*Shuai Mao,*Jun Lin,*Yinchun Jiao,*Yi Jin.*Cu-Catalyzed Radical Addition and Oxidation Cascade: Unsymmetrical Trimerization of Indole to Access Isotriazatruxene.Organic Letters2022,24, 1502-1506.

6) Kaixiu Luo,#Shuai Mao,#Kun He, Xianglin Yu, Junhong Pan, Jun Lin,* ZhiHui Shao,* Yi Jin*. Highly Regioselective Synthesis of Multisubstituted Pyrroles via Ag-Catalyzed[4+1C]insertCascade.ACS Catal.2020,10,3733–3740.

7) Shuai Mao,Kaixiu Luo, Lu Wang, Hong-Yi Zhao, Andrea Shergalis, Minhang Xin, Nouri Neamati,* Yi Jin,* and San-Qi Zhang*, Metal-Free C-2-H Alkylation of Quinazolin-4-ones with Alkanes via Cross-Dehydrogenative Coupling.Org. Lett.2019,21,2365–2368.

8) Shuai Mao,Zhengkai Chen, Lu Wang, Daulat Bikram Khadka, Minhang Xin, Pengfei Li*, and San-Qi Zhang*,Synthesis of Aryl Trimethylstannane via BF3·OEt2-Mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature,J. Org. Chem.2019,84,463–471.

9) Shuai Mao,Ya-Ru Gao, Xue-Qing Zhu, Dong-Dong Guo, and Yong-Qiang Wang*, Copper-Catalyzed Radical Reaction of N–Tosylhydrazones: Stereoselective Synthesis of (E)-Vinyl Sulfones.Org. Lett.2015,17,1692–1695.

10) Shuai Mao, Xue-Qing Zhu, Ya-Ru Gao, Dong-Dong Guo, Yong-Qiang Wang*,Silver-Catalyzed Two Csp3–H Coupling and One-pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles.Chem. Eur. J.2015, 11335-11339.

11) Shuai Mao,Ya-Ru Gao, Shao-Liang Zhang, Dong-Dong Guo, Yong-Qiang Wang*, Copper(II)-Promoted C–C Bond Formation by Oxidative Activation of Two C(sp3)–H Bonds Adjacent to Carbonyl Group to Construct 1,4-Diketones and Tetrasubstituted Furans.Eur. J. Org. Chem.2015, 876–885.

12) Jing-Wen Yu#,Shuai Mao#,Yong-Qiang Wang*, Copper-catalyzed base- accelerated direct oxidation of C–H bond to synthesize benzils, isatins, and quinoxalines with molecular oxygen as terminal oxidant.Tetrahedron Lett.2015,56,1575–1580.

13) Rui-Lin Liu*,Shuai Mao,Yan Wang, Lu Wang, Yan-Hui Ge, Xin-Ya Xu, Qiang Fu*. A mussel-inspired hybrid copolymer adhered to chitosan-coated micro-sized carbon fiber aerogels for highly efficient nanoparticle scavenging.Environ. Sci.: Nano,2017,4,2164-2174.

14) Guanghui Wang, Li Liu, Hong Wang, You-Song Ding, Jing Zhou,Shuai Mao,Pengfei Li*. N,B-Bidentate Boryl Ligand-Supported Iridium Catalyst for Efficient Functional-Group-Directed C–H Borylation.J. Am. Chem. Soc.2017,139,91.

15) Hong-Yi Zhao, Hai-Peng Wang, Yu-Ze Mao, Hao Zhang, Minhang Xin, Xiao-Xiao Xi, Hao Lei,Shuai Mao,Dong-Hui Li, San-Qi Zhang,* Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.J. Med. Chem.2022,65, 4709–4726.

专利:

1) 毛帅,袁博,张三奇,赵亚浩,王欣宇,王睿喆。一种硒醚/硫醚化合物的合成方法及合成的化合物,CN 114014790 A

2) 毛帅,袁博,张三奇,陈艺铭,赵亚浩,王欣宇。一种Ir-O-P型催化剂二硼酸/酯化合物的制备,CN 113980044 A

3) CPT专利:Nouri Neamati andShuai Mao, Preparation of substituted bicyclic and tetracyclic quinones and related methods of use. WO 2020181207.(已转化)

4) 毛帅,张三奇,辛敏行,赵宏义,雷浩。一种非金属促进的2-烷基杂芳烃化合物的制备方法,ZL 2019 1 1033939.7

联系方式:wlu890613 (微信)

电子邮箱:smao0115@xjtu.edu.cn

联系电话:15339028557

个人主页:https://gr.xjtu.edu.cn/web/smao0115/home

联系地址:陕西省西安市雁塔区雁塔西路76号西安交通大学药学院