研究领域（方向）

药物分析新方法、新材料、新装置

色谱分析新方法

天然活性成分发现与作用机制

个人及工作简历

科研项目

学术及科研成果、专利、论文

科研成果

[1] 细胞膜色谱技术及其在中药筛选中的应用, 国家技术发明二等奖，国务院，2012年，浪冲；王嗣岑；杨广德；袁秉祥；李西玲；张彦

[2] 秦巴山区特有活性生物碱结构优化关键技术体系及其应用, 陕西省技术发明二等奖，陕西省人民政府, 2020年，张杰; 卢闻; 王嗣岑; 单媛媛; 潘晓艳; 李鹏飞

[3] 秦巴山区特有活性生物碱(Taspine)的结构优化研究, 陕西省高等学科科学技术一等奖，陕西省教育厅, 2019年，张杰; 卢闻; 单媛媛; 潘晓艳; 代秉玲; 李鹏飞; 师亚玲; 魏芬; 司茹

[4]二维联用色谱技术在药物筛选和乳制品分析中的应用, 陕西省科学技术二等奖，陕西省人民政府, 2016年，王嗣岑；侯晓芳；韩省力；张涛；解笑瑜；单媛媛; 施晓光; 任丽萍; 陈德俊

代表性专利

[1] 王嗣岑; 李婷; 徐珂; 贺建宇; 张杰; 贺浪冲，2021年，红毛新碱在制备抗良性前列腺增生药物中的应用，ZL 201910138290.9，中国，未转让

[2] 王嗣岑; 张杰; 沈秀秀; 贺浪冲; 潘晓艳，2016年, 一种合成甲基红毛新碱的方法，ZL 201510394514.4，中国，未转让

[3] 王嗣岑; 贺浪冲; 黄静; 张涛; 张杰; 李西玲; 魏芬，2016年, 一种基于微载体细胞的细胞固定相及其制备方法, ZL 201310419338.6，中国，已转让

[4] 李昂; 王嗣岑; 苟建重; 孙俊毅，2017年, 黄芩及骨碎补有效部位配伍组方治疗牙周炎的制剂，ZL 201310686980.0，中国，未转让

[5] 李昂; 王嗣岑; 苟建重; 孙俊毅，2017年, 利用黄连及骨碎补有效部位配伍组方治疗牙周炎的制剂，ZL 201310669976.3，中国，未转让

代表性论文

[1] Yusi Bu, Qi Hu, Tao Bao, Xiaoyu Xie*, Sicen Wang*. 2022. Recent advances in cell membrane-coated technology for drug discovery from natural products. TrAC Trends in Analytical Chemistry, 151, 116601.

[2] Qi Hu, Lanlan Jia, Xiaolin Zhang, Aihong Zhu, Sicen Wang, Xiaoyu Xie*. (2022). Accurate construction of cell membrane biomimetic graphene nanodecoys via purposeful surface engineering to improve screening efficiency of active components of traditional Chinese medicine. Acta Pharmaceutica Sinica B, 12, 394-405.

[3] Yusi Bu, Xiaolin Zhang, Aihong Zhu, Linhao Li, Xiaoyu Xie*, Sicen Wang*. 2021. Inside-out-oriented cell membrane biomimetic magnetic nanoparticles for high-performance drug lead discovery. Analytical Chemistry, 93, 7898-7907.

[4] Wanghui Jing, Sijing Dong, Xialin Luo, Jingjing Liu, Bin Wei, Wei Du, Lin Yang, Hua Luo, Yitao Wang, Sicen Wang*, Haitao Lu*. (2021). Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacological Research, 164:105358.

[5] Nan Zhang, Yan Gao, Xianliang Xu, Tao Bao*, Sicen Wang*, (2021). Hydrophilic carboxyl supported immobilization of UiO-66 for novel bar sorptive extraction of non-steroidal anti-inflammatory drugs in food samples, Food Chemistry, 355, 129623.

[6] Yusi Bu, Xiaolin Zhang, Aihong Zhu, Linhao Li, Xiaoyu Xie*, Sicen Wang*. (2021). Inside-out-oriented cell membrane biomimetic magnetic nanoparticles for high-performance drug lead discovery. Analytical Chemistry, 93, 7898-7907.

[7] Yusi Bu, Qi Hu, Xiaolin Zhang, Ting Li, Xiaoyu Xie*, Sicen Wang*. (2020). A novel cell membrane-cloaked magnetic nanogripper with enhanced stability for drug discovery. Biomaterials Science, 8, 673-681.

[8] Qi Hu, Yusi Bu, Xueyan Zhen, Ke Xu, Ruifang Ke, Xiaoyu Xie*, Sicen Wang*. (2019). Magnetic carbon nanotubes camouflaged with cell membrane as a drug discovery platform for selective extraction of bioactive compounds from natural products. Chemical Engineering Journal, 364, 269-279.

[9] Xiaoyu Xie, Qi Hu, Ruifang Ke, Xueyan Zhen, Yusi Bu, Sicen Wang*. 2019. Facile preparation of photonic and magnetic dual responsive protein imprinted nanomaterial for specific recognition of bovine hemoglobin. Chemical Engineering Journal (IF: 13.273), 371, 130-137.

[10] Yusi Bu, Qi Hu, Ke Xu, Xiaoyu Xie*, Sicen Wang*. (2018). Improved cell membrane bioaffinity sample pretreatment technique with enhanced stability for screening of potential allergenic components from traditional Chinese medicine injection. Journal of Materials Chemistry B, 2018, 6, 624-633.

联系方式

电子邮箱：wangsc@mail.xjtu.edu.cn

联系电话：029-82655424