[4] 秦岭天然药物活性组分发现与结构优化创新团队,陕西省创新人才推进计划-科技创新团队(2019TD-017), 2019-05至2022-05, 主持, 60万元
[5] 固定化FGFR4高表达细胞色谱新方法的建立及在“七药”活性成分分析中的应用,国家自然科学基金项目(81673398), 2017-01至2020-12, 主持, 65万元
科研成果
[1] 细胞膜色谱技术及其在中药筛选中的应用, 国家技术发明二等奖,国务院,2012年,浪冲;王嗣岑;杨广德;袁秉祥;李西玲;张彦
[2] 秦巴山区特有活性生物碱结构优化关键技术体系及其应用, 陕西省技术发明二等奖,陕西省人民政府, 2020年,张杰; 卢闻; 王嗣岑; 单媛媛; 潘晓艳; 李鹏飞
[3] 秦巴山区特有活性生物碱(Taspine)的结构优化研究, 陕西省高等学科科学技术一等奖,陕西省教育厅, 2019年,张杰; 卢闻; 单媛媛; 潘晓艳; 代秉玲; 李鹏飞; 师亚玲; 魏芬; 司茹
[4]二维联用色谱技术在药物筛选和乳制品分析中的应用, 陕西省科学技术二等奖,陕西省人民政府, 2016年,王嗣岑;侯晓芳;韩省力;张涛;解笑瑜;单媛媛; 施晓光; 任丽萍; 陈德俊
代表性专利
[1] 王嗣岑; 李婷; 徐珂; 贺建宇; 张杰; 贺浪冲,2021年,红毛新碱在制备抗良性前列腺增生药物中的应用,ZL 201910138290.9,中国,未转让
[2] 王嗣岑; 张杰; 沈秀秀; 贺浪冲; 潘晓艳,2016年, 一种合成甲基红毛新碱的方法,ZL 201510394514.4,中国,未转让
[3] 王嗣岑; 贺浪冲; 黄静; 张涛; 张杰; 李西玲; 魏芬,2016年, 一种基于微载体细胞的细胞固定相及其制备方法, ZL 201310419338.6,中国,已转让
[4] 李昂; 王嗣岑; 苟建重; 孙俊毅,2017年, 黄芩及骨碎补有效部位配伍组方治疗牙周炎的制剂,ZL 201310686980.0,中国,未转让
[5] 李昂; 王嗣岑; 苟建重; 孙俊毅,2017年, 利用黄连及骨碎补有效部位配伍组方治疗牙周炎的制剂,ZL 201310669976.3,中国,未转让
代表性论文
[1] Yusi Bu, Qi Hu, Tao Bao, Xiaoyu Xie*, Sicen Wang*. 2022. Recent advances in cell membrane-coated technology for drug discovery from natural products. TrAC Trends in Analytical Chemistry, 151, 116601.
[2] Qi Hu, Lanlan Jia, Xiaolin Zhang, Aihong Zhu, Sicen Wang, Xiaoyu Xie*. (2022). Accurate construction of cell membrane biomimetic graphene nanodecoys via purposeful surface engineering to improve screening efficiency of active components of traditional Chinese medicine. Acta Pharmaceutica Sinica B, 12, 394-405.
[3] Yusi Bu, Xiaolin Zhang, Aihong Zhu, Linhao Li, Xiaoyu Xie*, Sicen Wang*. 2021. Inside-out-oriented cell membrane biomimetic magnetic nanoparticles for high-performance drug lead discovery. Analytical Chemistry, 93, 7898-7907.
[4] Wanghui Jing, Sijing Dong, Xialin Luo, Jingjing Liu, Bin Wei, Wei Du, Lin Yang, Hua Luo, Yitao Wang, Sicen Wang*, Haitao Lu*. (2021). Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacological Research, 164:105358.
[5] Nan Zhang, Yan Gao, Xianliang Xu, Tao Bao*, Sicen Wang*, (2021). Hydrophilic carboxyl supported immobilization of UiO-66 for novel bar sorptive extraction of non-steroidal anti-inflammatory drugs in food samples, Food Chemistry, 355, 129623.
[6] Yusi Bu, Xiaolin Zhang, Aihong Zhu, Linhao Li, Xiaoyu Xie*, Sicen Wang*. (2021). Inside-out-oriented cell membrane biomimetic magnetic nanoparticles for high-performance drug lead discovery. Analytical Chemistry, 93, 7898-7907.
[7] Yusi Bu, Qi Hu, Xiaolin Zhang, Ting Li, Xiaoyu Xie*, Sicen Wang*. (2020). A novel cell membrane-cloaked magnetic nanogripper with enhanced stability for drug discovery. Biomaterials Science, 8, 673-681.
[8] Qi Hu, Yusi Bu, Xueyan Zhen, Ke Xu, Ruifang Ke, Xiaoyu Xie*, Sicen Wang*. (2019). Magnetic carbon nanotubes camouflaged with cell membrane as a drug discovery platform for selective extraction of bioactive compounds from natural products. Chemical Engineering Journal, 364, 269-279.
[9] Xiaoyu Xie, Qi Hu, Ruifang Ke, Xueyan Zhen, Yusi Bu, Sicen Wang*. 2019. Facile preparation of photonic and magnetic dual responsive protein imprinted nanomaterial for specific recognition of bovine hemoglobin. Chemical Engineering Journal (IF: 13.273), 371, 130-137.
[10] Yusi Bu, Qi Hu, Ke Xu, Xiaoyu Xie*, Sicen Wang*. (2018). Improved cell membrane bioaffinity sample pretreatment technique with enhanced stability for screening of potential allergenic components from traditional Chinese medicine injection. Journal of Materials Chemistry B, 2018, 6, 624-633.