研究领域（方向）

专 业： 药物分析学

研究领域：

1）中药物质基础分析

2）生物活性色谱分析

3）色谱质谱联用分析

4）中药注射液安全性评价

个人及工作简历

科研项目

学术及科研成果、专利、论文

[1]Yuanyuan Lin, Qianqian Jia, Wei Sun, Jia Fu, Yanni Lv, Yajing Hou, Cheng Wang,Shengli Han*. Multi targeted cell membrane chromatography: A comprehensive method for screening the anaphylactoid components from complex samples. Talanta, 2020, 209: e120539.

[2] Yanni Lv, Jia Fu, Qianqian Jia, Hengtao Dong,Shengli Han*,Lingjun Li*, Langchong He. A liquid chromatography tandem mass spectrometry based label-free quantification method for assessment of allergen-induced anaphylactoid reactions. Journal of the American Society for Mass Spectrometry, 2020, 31: 856-863.

[3]Yuanyuan Lin, Jing Xu, Qianqian Jia, Wei Sun, Jia Fu, Yanni Lv,Shengli Han*. Cell membrane chromatography coupled online with HPLC-ESI-IT-TOF-MS method to screen anti-anaphylactoid components from Magnolia biondii Pamp.targeting on MrgprX2 receptor. Journal of Separation Science, 2020, 43: 2571-2578.

[4]Qianqian Jia, Wei Sun, Liyang Zhang, Jia Fu, Yanni Lv, Yuanyuan Lin,Shengli Han*. Screening the anti‐allergic components in Saposhnikoviae Radix using high‐expression Mas‐related G protein‐coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry. Journal of Separation Science, 2019, 42: 2351-2359

[5]Yanni Lv, Xianpeng Shi, Jia Fu, Qianqian Jia, Yuanyuan Lin, Hongying Wang, Xin Yang,Shengli Han*. Screening potential antagonists of epidermal growth factor receptor from Marsdenia tenacissima via cell membrane chromatography model assisted by HPLC–ESI–IT–TOF–MS. Biomedical Chromatography, 2019, 33: e4569.

[6]Jia Fu, Yanni Lv, Qianqian Jia, Yuanyuan Lin,Shengli Han*. Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. Talanta, 2019, 192: 248-254.

[7]Yanni Lv, Jia Fu, Qianqian Jia, Delu Che, Yuanyuan Lin,Shengli Han*, Langchong He. Accurate quantification of β-hexosaminidase released from laboratory of allergic diseases 2 cells via liquid chromatography tandem mass spectrometry method. Journal of Chromatography A, 2018, 1578:106-111.

[8]Yuanyuan Lin, Yanni Lv, Jia Fu, Qianqian Jia,Shengli Han*. A high expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled with liquid chromatography and mass spectrometry method for screening potential anaphylactoid components in kudiezi injection. Journal of Pharmaceutical and Biomedical Analysis, 2018, 159: 483-489.

[9]Shengli Han, Yanni Lv, Fen Wei, Jia Fu, Qi Hu, Sicen Wang. Screening of bioactive components from traditional Chinese medicines using cell membrane chromatography coupled with mass spectrometry. Phytochemical Analysis, 2018, 29: 341-350.

[10]Shengli Han, Yanni Lv, Liyun Kong, Yueming Sun, Jia Fu, Lingjun Li, Langchong He. Simultaneous identification of the anaphylactoid components from Traditional Chinese Medicine injections using rat basophilic leukemia 2H3 and laboratory of allergic disease 2 dual-mixed/cell membrane chromatography model. Electrophoresis, 2018, 39: 1181-1189

[11]Shengli Han, Yanni Lv, Liyun Kong, Delu Che, Rui Liu, Jia Fu, Jiao Cao, Jue Wang, Cheng Wang, Huaizhen He, Tao Zhang, Xinzhong Dong, Langchong He. Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs. Scientific Reports, 2017, 7:13714.

[12]Yanni Lv, Jia Fu, Xianpeng Shi, Zhiwei Yang,Shengli Han*. Screening allergic components of Yejuhua injection using LAD2 cell membrane chromatography model online with HPLC-IT-TOF-MS system. Journal of Chromatography B, 2017, 1055-1056: 119-124.

[13]Fen Wei, Qi Hu, Jing Huang,Shengli Han*, Sicen Wang. Screening active compounds from Corydalis yanhusuo by combining high expression VEGF receptor HEK293 cell membrane chromatography with HPLC - ESI - IT - TOF - MSn method. Journal of Pharmaceutical and Biomedical Analysis, 2017, 136: 134-139.

[14]Yanni Lv, Yueming Sun, Jia Fu, Liyun Kong,Shengli Han*. Screening anti-allergic components of Astragali Radix using LAD2 cell membrane chromatography coupled online with UHPLC-ESI-MS/MS method. Biomedical Chromatography, 2017, 31: e3806, 1-7.

[15]Shengli Han, Yanni Lv, Wenjing Xue, Jiao Cao, Ronghua Cui, Tao Zhang. Screening anaphylactic components of MaiLuoNing injection by using rat basophilic leukemia-2H3 cell membrane chromatography coupled with high-performance liquid chromatography-electrospray ionization-ion trap-time of flight-mass spectrometry. Journal of Separation Science, 2016, 39: 466-472.

[16]Shengli Han, Chunlei Li, Jing Huang, Fen Wei, Yu Zhang, Sicen Wang. Cell membrane chromatography coupled with UHPLC–ESI–MS/MS method to screen target components from Peucedanum praeruptorum Dunn acting onα1A adrenergic receptor. Journal of Chromatography B, 2016, 1011: 158-162.

[17]Jiangbo Fan, Fen Wei, Yu Zhang, Hongli Su, Zongzheng Ji, Jianyu He*,Shengli Han*. Combining Sprague–Dawley rat uterus cell membrane chromatography with HPLC/MS to screen active components from Leonurus Artemisia. Pharmaceutical Biology, 2016, 54: 279-284.

[18]Shengli Han, Jing Huang, Ronghua Cui, Tao Zhang. Screening antiallergic components from Carthamus tinctorius using rat basophilic leukemia 2H3 cell membrane chromatography combined with high-performance liquid chromatography and tandem mass spectrometry. Journal of Separation Science, 2015, 38: 585-591.

[19]Shengli Han, Tao Zhang, Ting Li, Liyun Kong, Yanni Lv, Langchong He. A sensitive HPLC-ECD method for detecting serotonin released by RBL-2H3 cells stimulated by potential allergens. Analytical Methods, 2015, 7: 8918-8924.

[20]Shengli Han, Tao Zhang, Jing Huang, Ronghua Cui, Langchong He. New method of screening allergenic components from Shuanghuanglian injection: With RBL-2H3/CMC model online HPLC/MS system. Journal of Pharmaceutical and Biomedical Analysis, 2014, 88: 602-608.

[21]Shengli Han, Jing Huang, Jingjing Hou, Sicen Wang. Screening epidermal growth factor receptor antagonists from Radix et Rhizoma Asari by two-dimensional liquid chromatography. Journal of Separation Science, 2014, 37: 1525-1532.

[22]Shengli Han, Fen Wei, Jing Huang, Sicen Wang. Characterization of compounds acting on theα1a adrenergic receptor from Caulis Spatholobi by cell membrane chromatography with possible application for treatment of benign prostatic hyperplasia. Analytical Letters, 2014, 47: 1661-1669.

[23]Shengli Han, Tao Zhang, Liuxin Feng, Nan Lv, Sicen Wang. Screening of target compounds from Fructus Piperis using highα1A adrenoreceptor expression cell membrane chromatography online coupled with high performance liquid chromatography tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2013, 81-82: 133-137.

[24]Shengli Han, Tao Zhang, Jing Huang, Zhigang Hu, Sicen Wang. Screening target components from Radix salviae miltiorrhiae using an EGFR/CMC-online-HPLC/MS method. Analytical Methods, 2012, 4: 1078-1083.

[25]Shengli Han, Peng Zhang, Fen Wei Sicen Wang. Screening active components acting on a1A adrenergic receptors from agrimony using a Sprague-Dawley rat prostate cell membrane chromatography online coupled HPLC/MS method. Analytical Methods, 2012, 4: 3351-3357.

联系方式

电子邮箱：slhan2008@mail.xjtu.edu.cn

联系电话：029-82655451